Titan Krios Laboratory
To be situated at the Peter Gilgan Centre for Research and Learning, the Titan Krios Transmission Electron Microscope (TEM) facility is a partnership project between three academic institutions – SickKids Research Institute, Princess Margaret Cancer Centre and University of Toronto.
The Titan Krios is tailored for use in protein and cellular imaging. Its revolutionary cryo-based technology and stability permits a full range of semi-automated applications, including 2D electron crystallography, single particle analysis, cryo electron microscopy, and dual-axis cellular tomography of frozen hydrated cell organelles and cells. Cryo techniques preserve sample integrity by maintaining the sample in its natural condition and state. The Titan Krios’ versatility ensures the ability to perform today’s experiments as well as address new research problems in the future. It is the most powerful and flexible high resolution electron microscope for 3D characterization of biological samples. The innovative enclosed platform combines excellent optical performance and thermal and mechanical stability with a high throughput sample loader.
The designed space that houses this instrument requires specific environmental controls. These controls will include a dedicated HVAC system for constant temperature and low humidity (<20% RH at 21 degrees Celsius) and a magnetic field cancellation system to compensate for the slowly varying pseudo-DC magnetic fields found throughout Toronto.
Schematic Design Complete
The space in the existing SickKids Hospital's Burton Wing consists of 12,000 square feet of floor space that will be partially demolished for the new Modular Clinic. SickKids intends to establish a state of the art solution that will allow the organization to trial the results of their deign innovation. The goal of the solution is to achieve flexibility of function, provide improved patient and family care and create an incubator of change for the long-term delivery of ambulatory care. This project is about physical solutions but also about engaging the organization in creating a measurable change in care delivery with more stringent operational goals. An array of programs has been selected for the new Modular Clinic redevelopment based on their current success in hosting multidisciplinary clinics.
Various Base Building Upgrades
Cumulus has also worked with SickKids to make a number of improvements to the Peter Giligan Centre for Research and Learning (PGCRL) that address lobby security, occupational health and safety, and environmental comfort. Modifications include cost effective retrofits to south facing glazing that reduce glare while preserving views and respecting the building’s original aesthetic. A new stainless steel bench solution was also added at the building's south and east stone base to provide a more comfortable sitting space for the general public.